Módulo 2 – Curso pós-graduado – VIH e Envelhecimento

Non-AIDS Defining Cancers Among HIV Infected People

Clinical Management of non-AIDS defining cancers

Key messages

  • The incidence of NADC is higher among HIV-infected indivi- duals, which account for the majority of malignancies of these patients.
  • Lung cancer, HL, anogenital HPV-related neoplasias, and hepatocellular carcinoma are among the most frequent NADC in HIV patients.
  • Management of NADC requires a multidisciplinary approach, involving both oncologists and HIV physicians, and should follow the same guidelines as for the general population.
  • Antiretroviral drugs can cause clinically relevant drug interactions, which may occur by inhibition or induction of enzymes or transporters, or by changes in the absorption mechanisms.
  • Drug interactions between anti-cancer and anti-HIV drugs are critical. Whenever possible, antiretroviral drugs with less potential for interactions should be used, namely the integrase inhibitors.
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