Módulo 2 – Curso pós-graduado – VIH e Envelhecimento

Non-AIDS Defining Cancers Among HIV Infected People

Risk factors for non-AIDS defining malignancies

Autor: Prof. Doutor Mark Bower, MD PhD (National Centre for HIV malignancy Chelsea & Westminster Hospital, London, UK)

How to stop patients getting NADM

In the UK, it is estimated that 42% of all cancers are preventable, with 19% of all cancers being due to smoking and 9% due to diet. In addition, other factors may be described for the HIV population.

The SMART trial evaluated earlier initiation of ART and included several endpoints related to NADMs10. HIV patients with immediate initiation of ART had a reduction in the risk of AIDS- defining cancers, compared to the people with deferred initia- tion of ARV, with a significant reduction in the development of Kaposi’s sarcoma (p=0.02). Although not statistically significant, the incidence rate of NADMs was doubled for patients who deferred initiation of ARV (0.26 vs. 0.13 per 100 person-year). Hence, starting ART earlier may also reduce the patients’ risk of NADMs.

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