Módulo 2 – Curso pós-graduado – VIH e Envelhecimento

Non-AIDS Defining Cancers Among HIV Infected People

Risk factors for non-AIDS defining malignancies

Autor: Prof. Doutor Mark Bower, MD PhD (National Centre for HIV malignancy Chelsea & Westminster Hospital, London, UK)

Age as a risk factor for cancer

In 2014, a total of 110,000 people were living with HIV in the United Kingdom (UK). There were about 6,000 new HIV diagnosis and only 527 deaths, resulting in the growth of HIV population by 5%. More than a quarter of the population (27%) of people living with HIV was older than 50 years in 2013.

Age is the biggest risk factor for cancer. The incidence of cancer, overall, rises with increased age. It has been estimated that, by the year 2020, in the UK, one in two people will develop a cancer in some point during their lives.

Besides the increased risk of cancer, the types of cancer also vary with age. For instance, amongst men aged 25-49 years old, testicular cancer is the most common cancer, but other cancers such as prostate, lung and bowel cancers became more frequent above this age. Hence, as the HIV population ages, not only are more cancers to be expected, but also a change in the spectrum of NADMs away from testicular cancer and melanoma, and towards the common epithelial cancers6.

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